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Combination with Image Analysis:

Combining spectroscopic data with morphological information, such as particle size and shape, provides access to an array of characteristics that were previously unavailable. For example, the new methods allow for the specific chemical characterization of hundreds of elongated, fibrous or more compacted round particles. These technological advances bring a whole new dimension to particle analyticsl. The ability to determine relevant particle characteristics and the capacity to set tailor-made parameters for specialty products such as dry powder inhalers design sets this technology far apart from it's competitors.

4.01. Particle:(x,y): 1025, 60 Length: 121, Class:5, L/W:1.6, Exp:1.0 s, T: -45°C  
RESULT: Poly(styrene)
RANK: 810, S/N: 35.3
 


Automated Spectroscopy - Statistical Relevance:

Automated analysis systems provide objective results. It is impossible for an operator to select hundreds or thousands of particles as small as 2-500μm for spectroscopic analysis individually. Ultimately, the result will be subjective because the user tends to develop a liking for particles which yield beautiful spectra or have a distinctive shape. The Particle Explorer lets you obtain reliable unbiased results.
The automated Raman spectroscopy system selects the appropriate laser intensity and exposure time to achieve optimal spectra. Intended for smaller particles and a rapid completion, the standard version provides a reliable particle spectrum within 10 to 60 seconds.The newly-developed Ultra Raman module, 10 times more sensitive as the previous, reduces analysis time to less than 1 second. This is particularly recommended when analyzing particles between 2µm and smaller than 5μm in diameter.

Image Analysis:

The result of the automated measurement is available within approx. 2 hours of analysis time.

Substance Particle Total Size
2 - 5 µm
Size
5 - 10 µm
Size
10 - 25 µm
Size
25 - 50 µm
Size
50 - 100 µm
Size
> 100 µm
Talcum 26 17 7 9 21 10 0
PVA 59 146 22 12 34 7 7
Polypropylene 154 29 2 56 0 59 4
Polystyrene 270 58 34 20 0 20 20
Protein 291 97 0 27 24 44 14
Analyzed 800 347 65 124 79 140 45
Particle Total 6516 2368 1976 459 846 660 207


A total of 800 particles were selected for analysis, the majority being protein particles, the primary source of contamination.